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Evaluation of Biomarkers in Human Synovial Fluid

NCT02664870 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 149

Last updated 2026-02-04

No results posted yet for this study

Summary

Osteoarthritis is a condition that causes joints in the human body to deteriorate over time. This condition affects more than 250 million people around the globe. Currently, the goal of treating osteoarthritis involves reducing the severity and pain that results from the disease. The ultimate goal of this study is to identify patients with pre-arthritic joints (before symptoms or disease characteristics appear) in an effort to find and use treatments that stop or slow the disease. Joints are filled with a naturally occurring liquid known as synovial fluid. Molecules (biomarkers) and genetic expression of various cell types within synovial joint fluid may serve as measures of onset and progression of osteoarthritis. These samples have the potential to improve diagnosis, classification, and treatment, possibly changing the natural history of this debilitating disease. The purpose of this study is to develop a collection of synovial fluid samples from the shoulder, hip and knee for the analysis of biomarkers and cellular and genetic components therein to better understand the pre-arthritic joint, progression to disease, and response to interventions.

Conditions

Interventions

PROCEDURE

Arthroscopy

Arthroscopic Surgery on the hip, shoulder, or knee

PROCEDURE

Arthroplasty

Total hip, shoulder, or knee arthroplasty

Sponsors & Collaborators

Principal Investigators

  • Richard C. Mather, MD, MBA · Duke University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-31
Primary Completion
2019-01-24
Completion
2028-01-01

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02664870 on ClinicalTrials.gov