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Role of Bone in Knee Osteoarthritis (OA)

NCT00850538 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 101

Last updated 2015-12-04

Study results available
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Summary

The purpose of the study is to investigate protein and gene expression among damaged knee tissues. We will perform MRI's on subjects prior to total knee replacement to identify the location of bone marrow lesions. Connective tissues including tendon, ligament, and meniscus specimens normally discarded from total joint replacements will be used for live cell harvest, and protein and gene expression analyses of tissue or cultured cells.

Conditions

  • Osteoarthritis, Knee

Interventions

RADIATION

MRI

1.5T MRI exam of signal knee with knee coil (estimated time: 35 minutes)

PROCEDURE

Primary Total Knee Replacement

Fluid, bone, and meniscus specimens obtained from total joint replacement will be collected.

Sponsors & Collaborators

  • The New England Baptist Hospital

    lead OTHER

Principal Investigators

  • David Hunter, MD · University of Sydney

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-07-31
Primary Completion
2013-04-30
Completion
2013-04-30

Countries

  • Australia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00850538 on ClinicalTrials.gov