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Analysis of Human Knee Joint Fluid Using Metabonomic, Genomic and Tribology Techniques

NCT02565160 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2019-08-20

No results posted yet for this study

Summary

Making the diagnosis underlying a painful, swollen joint currently involves aspiration followed by numerous microbiological and biochemical laboratory tests. This can be costly, time consuming and in the case of an acutely swollen joint, lead to a lengthy inpatient admission. There is an unmet need to provide a quick, easy, reliable dipstick like test to analyse joint fluid in the community, clinic, or emergency department setting.

The investigators aim to use well established metabonomic techniques to:

1. Analyse fluid from patients with swollen joints
2. Identify potential biomarkers of inflammatory, infective and osteoarthritic causes of joint swelling
3. Correlate this with lubrication and wear properties of the fluid The long term goal is to develop time saving, cost effective, non-invasive diagnostic tests to improve management of a swollen joint. The biomedical research centre at Imperial provides a unique and unparalleled clinical and scientific environment to conduct this research. The Imperial College division of Computational and Systems Medicine has an international reputation in metabonomics and this, together with the high volume of patients with swollen joints treated at Imperial National Health Service Trust (c1000/yr) ensures that the study can take place in an environment conductive to success.

Conditions

Interventions

PROCEDURE

Intra-articular aspiration of Joint

Procedural sampling of the joint for diagnostic purposes

PROCEDURE

Joint irrigation washout

Procedural washout for treatment purposes

PROCEDURE

Total Joint Arthroplasty

PROCEDURE

Revision Joint Arthroplasty

Sponsors & Collaborators

  • Imperial College London

    lead OTHER

Principal Investigators

  • Chinmay Gupte, MBBChir · Imperial College London

Eligibility

Min Age
16 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-31
Primary Completion
2021-10-31
Completion
2021-10-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02565160 on ClinicalTrials.gov