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MRI Markers of Cartilage Damage in Knee With Osteoarthritis

NCT00820430 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 53

Last updated 2023-07-20

No results posted yet for this study

Summary

The objectives of this study are: to identify and develop techniques to minimize precision errors in magnetic resonance imaging (MRI) evaluation of knee cartilage, and to determine if results from newly-identified MRI techniques in measuring cartilage changes and structure can be reproduced.

Conditions

  • Osteoarthritis, Knee

Interventions

OTHER

Magnetic Resonance Imaging

Subjects will undergo 4 sequential MRI evaluations of the target knee within a 4 week period to calculate precision error (ICC) in determination of cartilage morphometry (cartilage volume, mean thickness, and surface area), cartilage collagen (regional cartilage T2), and cartilage proteoglycan (regional cartilage T1rho).

Sponsors & Collaborators

  • Pennsylvania Department of Health

    collaborator OTHER_GOV

  • American College of Radiology

    lead OTHER

Principal Investigators

  • Timothy J Mosher, MD · Milton S. Hershey Medical Center

  • Ravinder Reddy, PhD · University of Pennsylvania, MMRRCC

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-11-30
Primary Completion
2008-05-31
Completion
2008-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00820430 on ClinicalTrials.gov