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Effect of Trans Fatty Acids From Ruminant Sources on Risk Factors for Cardiovascular Disease

NCT00942656 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2011-02-09

No results posted yet for this study

Summary

The objectives of this study are to : 1) determine if vaccenic acid (trans-11-octadecenoic, a naturally occurring trans fatty acid isomer from ruminant animal products) raises LDL cholesterol in a quantitatively comparable manner as mixed trans fatty acid isomers from partially hydrogenated vegetable oils at 3% of energy intake, 2) determine if cis-9, trans-11 conjugated linoleic acid (a naturally occurring polyunsaturated fatty acid from ruminant animal products) raises LDL cholesterol compared to a control diet, and 3) demonstrate that mixed trans fatty acid isomers from partially hydrogenated vegetable oil raises LDL cholesterol compared to a low trans fatty acid diet.

Conditions

Interventions

OTHER

PHVO

base diet plus 3.0% energy mixed isomers of trans fatty acids from partially hydrogenated vegetable oil

OTHER

CLA

base diet plus 1.0% energy added from cis-9, trans-11 conjugated linoleic acid

OTHER

VA

base diet plus 3.0% energy added from vaccenic acid

OTHER

base

base diet containing approximately 0.1% energy of mixed trans fatty acid isomers

Sponsors & Collaborators

  • United States Department of Agriculture (USDA)

    lead FED

Principal Investigators

  • David J Baer, Ph. D. · United States Department of Agriculture (USDA)

Study Design

Allocation
RANDOMIZED
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
25 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-02-28
Primary Completion
2009-09-30
Completion
2009-09-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00942656 on ClinicalTrials.gov