MedTrace Logo

Coronary Blood Flow Regulation During General Anesthesia

NCT00866801 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2015-10-14

No results posted yet for this study

Summary

The central hypothesis in the present project is that general anesthesia may alter autonomic control such that perioperative coronary blood flow (CBF) is significantly disturbed.

These disturbances in coronary blood flow may contribute to the development of myocardial ischemia in the perioperative period. Furthermore, patients with an intrinsically altered autonomic sympathetic innervation, like diabetics, are even more prone to develop perioperative disturbances in coronary blood flow.

Here the researchers will investigate what the direct effects are of general and locoregional anesthesia on the CBF. Furthermore, the researchers aim to evaluate whether diabetic subjects show more disturbed CBF responses to anesthesia as compared to non-diabetics.

Conditions

  • Myocardial Ischemia
  • Autonomic Neuropathy
  • Healthy
  • Diabetes

Sponsors & Collaborators

  • Netherlands Heart Foundation

    collaborator OTHER

  • Amsterdam UMC, location VUmc

    lead OTHER

Principal Investigators

  • Carolien SE Bulte, MD · Amsterdam UMC, location VUmc

  • R. A. Bouwman, MD, PhD · Amsterdam UMC, location VUmc

  • C. Boer, PhD · Amsterdam UMC, location VUmc

  • S. A. Loer, MD, PhD, MSC · Amsterdam UMC, location VUmc

  • O. Kamp, MD, PhD · Amsterdam UMC, location VUmc

  • M. Diamant, MD, PhD · Amsterdam UMC, location VUmc

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-04-30
Primary Completion
2014-02-28
Completion
2014-10-31

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00866801 on ClinicalTrials.gov