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TEAM-Project: Trial on the Effect of Anesthetics on Morbidity and Mortality

NCT00286585 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 385

Last updated 2012-08-27

No results posted yet for this study

Summary

Volatile anesthetics may provide some protection from myocardial ischemia, an effect called anesthetic preconditioning. In patients undergoing coronary artery bypass surgery, this preconditioning effect resulted in better cardiac performance, faster recovery and lower morbidity and mortality.

The investigators will perform a prospective randomized multi-center study to compare volatile with total intravenous anesthesia in patients at a high cardiac risk who undergo major non-cardiac surgery.

Conditions

Interventions

DRUG

Inhalational anesthetic

Sevoflurane, dosage according to the physician in charge

DRUG

Intravenous anesthetic, propofol

Propofol, dosage according to the physician in charge

Sponsors & Collaborators

  • Abbott

    collaborator INDUSTRY

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Manfred Seeberger, Prof. Dr. · Department of Anesthesia, University Hospital, Basel, Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-02-28
Primary Completion
2010-11-30
Completion
2011-11-30

Countries

  • Switzerland

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00286585 on ClinicalTrials.gov