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The Effects of Anaesthesia on Cerebral Oxygenation and Cognitive Function in Carotid Endarterectomy

NCT02771418 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2016-09-22

No results posted yet for this study

Summary

Volatile anesthetics interfere with cerebral blood flow and reperfusion-ischemia injury via the mechanism known as a preconditioning. A transient deterioration of local hemodynamics and oxygenation during carotid endarterectomy (CEE) might involve both hemispheres of brain and affect postoperative cognitive function. The goal of this study was to assess the effects of anesthetics on perioperative cerebral oxygenation and cognitive functions.

Conditions

  • Endarterectomy
  • Postoperative Cognitive Dysfunction

Interventions

DRUG

Propofol

Intravenous induction and maintenance of general anesthesia with propofol is a routine practice for this intervention

DRUG

Sevoflurane

Volatile induction and maintenance of general anesthesia with sevoflurane is a generally acceptable clinical approach for this intervention

PROCEDURE

Elective carotid endarterectomy

Sponsors & Collaborators

  • Northern State Medical University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-02-28
Primary Completion
2016-06-30
Completion
2016-06-30

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02771418 on ClinicalTrials.gov