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Influence of Anesthesia on Mechanical Efficiency of Left Ventricle in Patients Undergoing Open Heart Surgery

NCT01397331 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 28

Last updated 2018-04-24

No results posted yet for this study

Summary

The aim of the study is to delineate and compare the changes in coupled mechanical properties of left ventricle and arterial vascular bed caused by two popular anesthetic protocols commonly used in cardiac surgery (intravenous, based on the infusion of propofol, versus inhalational, based on isoflurane) on different stages of the surgery.

Conditions

  • Heart; Dysfunction Postoperative, Cardiac Surgery
  • Disorder; Heart, Functional, Postoperative, Cardiac Surgery

Interventions

DRUG

Isoflurane

Anesthesia based on inhalation of 1-1.5 Minimal Alveolar Concentration of Isoflurane with the addition of infusion of remifentanil

DRUG

Propofol

Anesthesia based on the infusion of 2-5 mg/kg/h of propofol with the addition of infusion of remifentanil

Sponsors & Collaborators

  • Sheba Medical Center

    lead OTHER_GOV

Principal Investigators

  • Sergey Preisman, M.D. · Department of Anesthesia and Intensive Care, Sheba Medical Center, Israel 52621

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-07-01
Primary Completion
2012-06-27
Completion
2012-06-27

Countries

  • Israel

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01397331 on ClinicalTrials.gov