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The Pharmacokinetics of Opioids and Sedative/Hypnotics During Selective Cerebral Perfusion

NCT00494598 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 6

Last updated 2013-08-01

No results posted yet for this study

Summary

There is a need to understand how long anesthetic drugs last in the brain during surgery on the ascending aorta or aortic arch. Drugs can have a prolonged effect when blood temperature is made cold therefore the influence of temperature needs to be studied. This type of surgery allows us to answer questions about how anesthetic drugs behave when they are given during a routine portion of surgery. Patients will be provided with anesthetic drugs during surgery while on a heart lung machine. After the drug is injected into the heart lung machine it will be delivered to the brain to provide more sleep and pain relief. Immediately after the injection of anesthetic drugs, blood samples will be taken from an existing intravenous line in the neck and plasma drug concentrations measured. This will help us to understand how long drugs last in the brain during this type of surgery.

Conditions

  • Aortic Aneurysm

Interventions

DRUG

Sufentanil

200 mcg intra-arterial one time bolus

Sponsors & Collaborators

Principal Investigators

  • Ervant Nishanian, PhD MD · Columbia University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-03-31
Completion
2007-06-30

Countries

  • United States

Study Locations

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Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00494598 on ClinicalTrials.gov