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Chronic Inflammatory Activation in Fat Tissue: An Atherogenic Factor in Severe Coronary Artery Disease

NCT00510705 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 29

Last updated 2020-11-27

No results posted yet for this study

Summary

Chronic inflammatory activation in fat tissue can be the link between adiposity and an increased risk for atherosclerosis. The aim of this study is to investigate how molecular alterations in fat tissue can be influenced by regular physical exercise training alone or in combination with a medical therapy (glitazone or metformin) in obese patients with severe coronary artery disease (CAD) and impaired glucose tolerance.

Conditions

  • Severe Coronary Artery Disease
  • Obesity
  • Impaired Glucose Tolerance

Interventions

OTHER

exercise training

physical exercise training on a bicycle ergometer daily for 4 weeks

OTHER

exercise training + metformin

physical exercise training on a bicycle ergometer + metformin (2 x 850 mg) daily for 4 weeks

OTHER

exercise training + glitazone

physical exercise training on a bicycle ergometer + glitazone daily for 4 weeks

Sponsors & Collaborators

  • Heart Center Leipzig - University Hospital

    collaborator OTHER

  • University of Leipzig

    lead OTHER

Principal Investigators

  • Gerhard Schuler, Prof. of Medicine · Heart Center Leipzig - University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
35 Years
Max Age
75 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-07-31
Primary Completion
2012-07-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00510705 on ClinicalTrials.gov