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Exercise Response in Humans With Obesity

NCT05857150 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2025-08-29

No results posted yet for this study

Summary

This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.

Conditions

Interventions

DIAGNOSTIC_TEST

Treadmill Test

Measurement of whole-body fitness level. Walking or running on a treadmill and breathing into a machine that measures oxygen level during test. Heart rhythm is continuously monitored during exercise using an electrocardiogram (ECG).

DIAGNOSTIC_TEST

Strength Test

Measure the strength of leg muscles by kicking against a machine with resistance.

DIAGNOSTIC_TEST

Dual-Energy X-Ray Absorptiometry

Body composition measurement.

PROCEDURE

Muscle Biopsy

Obtain a small piece of muscles from the upper part of the legs

PROCEDURE

Fat Biopsy

Fat sample taken from abdomen

DIAGNOSTIC_TEST

Resting Energy Expenditure

Measured by indirect calorimetry. Measures how much energy the body uses at rest by placing a special plastic dome over the head while resting quietly for 30 minutes. Measures oxygen breathed in and carbon dioxide breathed out.

DIAGNOSTIC_TEST

Magnetic resonance imaging

MRI on upper leg to look at fat and muscle

Sponsors & Collaborators

Principal Investigators

  • Ian Lanza, PhD · Mayo Clinic

Eligibility

Min Age
20 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-22
Primary Completion
2029-07-31
Completion
2029-07-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05857150 on ClinicalTrials.gov