FatMax Training on Metabolic and Epigenetic Parameters

Summary

Exercise is an essential pillar for the health of all individuals, as it contributes to physical, mental, and emotional well-being. Various international organizations, such as the World Health Organization, advocate for the integration of exercise into healthy lifestyles, recognizing its im-portance in disease prevention and improving quality of life. However, despite the general consensus on its value, there is no universal agreement on specific prescriptions for vulnerable groups, highlighting the need for personalized approaches that consider the unique characteristics and needs of each individual. It has been proposed that a moderate aerobic exercise training program could promote positive outcomes in individuals living with overweight and obesity, particularly with an emphasis on reducing injury risk, ensuring high adherence, and achieving favorable health changes. In this regard, the present protocol establishes the basis for a randomized clinical trial based on exercise prescription at the maximal fat oxidation rate in young individuals with overweight and obesity, with a duration of 16 weeks. Throughout the study, biochemical changes (cholesterol, glucose, triglycerides, and inflammatory markers), metabolic changes (de-termination of fat and carbohydrate utilization rates during rest and exercise), and epigenetic changes (focusing on microRNAs associated with adipogenesis, inflammation, and fat metabolism) will be monitored.

Conditions

• Overweight and Obesity
• Body Weight Changes

Interventions

OTHER

FatMAx training intervention

FatMax training program on a treadmill or stationary bicycle, whichever is more convenient for them

OTHER

FatMax and physical endurance exercise intervention

FatMax training program on a treadmill or stationary bicycle, whichever is more convenient for them, with muscular endurance exercise

OTHER

Control

No intervention pf physical activity

Sponsors & Collaborators

• Universidad Autonoma de Baja California

  lead OTHER

Principal Investigators

• René Bassó-Quevedo, MSc · Bioethic Comittee of the Autonomous University of Baja California

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

35 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-01-01

Primary Completion

2026-08-01

Completion

2027-01-01

Countries

• Mexico

Study Locations