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Re-energize With Nutrition, Exercise and Weight Loss

NCT00712127 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 310

Last updated 2017-07-31

No results posted yet for this study

Summary

The purpose of this project is to establish a Center of Excellence in Research on Obesity that will focus on severe obesity. The prevalence of severe obesity (i.e., Class 2 and 3 obesity; body mass index \> 35 kg/m2 and 40 kg/m2) is increasing more rapidly than is overweight and Class 1 obesity. Treatment guidelines for severe obesity are uncertain.

Three novel hypotheses regarding the pathogenesis of severe obesity will be tested: a) using non-invasive methods to measure energy expenditure; b) conducting an annotated lipomic search for bio-markers of impaired fat oxidation; and c) examining the role of obesity-induced inflammation as a cause for leptin resistance. Responses will also be measured following intervention with diet and activity.

Conditions

Interventions

OTHER

Diet and Exercise

The participants in this intervention will receive 12 months of weight loss through diet and exercise

OTHER

Diet and Exercise-Delayed

Participants in this intervention will receive six months of weight loss through diet followed by six months of diet and exercise

Sponsors & Collaborators

Principal Investigators

  • Bret H. Goodpaster, Ph.D. · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-06-30
Primary Completion
2010-03-31
Completion
2010-05-31

Countries

  • United States

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00712127 on ClinicalTrials.gov