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Exercise Intolerance Study in Long Chain Fatty Acid Oxidation Disorders

NCT05924555 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2024-08-23

No results posted yet for this study

Summary

In this study, the exercise tolerance in patients with long-chain fatty acid oxidation disorders (LcFAOD) will be compared to that of healthy volunteers who are carefully matched in terms of age, sex, BMI and physical activity score. The study aims to assess exercise capacity using cardiopulmonary exercise (CPX) tests and activity monitoring over a 7-day period. The hypothesis of the study is that LcFAOD patients will exhibit greater oxygen debt during short periods of exercise compared to healthy individuals. These findings will contribute to a better understanding of exercise intolerance in LcFAOD patients and may guide the development of targeted interventions, such as exercise training programs and enable the analysis of effectiveness of (new) treatments.

Conditions

  • Long-chain Fatty Acid Oxidation Disorders

Interventions

OTHER

Intermittent cardiopulmonary exercise test

Exercise test with step-change from rest to a relatively low constant workload.

OTHER

Incremental cardiopulmonary exercise test

Exercise test with incremental workload until maximal workload.

OTHER

Echography of upper leg

Determine upper leg muscle size

OTHER

Hand grip strength with hand dynamometer

Determine muscle strength

OTHER

Fill in questionnaires regarding physical activity

SQUASH, mMRC, questionnaire designed to report myopathic symptoms in LcFAOD patients.

Sponsors & Collaborators

  • Stichting Stofwisselkracht

    collaborator UNKNOWN

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    lead OTHER

Principal Investigators

  • Mirjam Langeveld, MD PhD · Amsterdam UMC, location AMC

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-08-01
Primary Completion
2028-08-01
Completion
2028-08-01

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05924555 on ClinicalTrials.gov