TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma

Summary

RATIONALE: Less intensive therapy may attain in the same results as intensive therapy in children with non-Hodgkin's lymphoma.

PURPOSE: Randomized phase III trial to study the effectiveness of less intensive therapy for children who have non-Hodgkin's lymphoma.

Conditions

• Leukemia
• Lymphoma

Interventions

BIOLOGICAL

filgrastim

DRUG

cyclophosphamide

DRUG

cytarabine

DRUG

doxorubicin hydrochloride

DRUG

etoposide

DRUG

methotrexate

DRUG

prednisolone

DRUG

prednisone

DRUG

therapeutic hydrocortisone

DRUG

vincristine sulfate

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Societe Francaise Oncologie Pediatrique

  collaborator OTHER

• Children's Cancer and Leukaemia Group

  collaborator OTHER

• Children's Oncology Group

  lead NETWORK

Principal Investigators

• Mitchell S. Cairo, MD · Herbert Irving Comprehensive Cancer Center

• Catherine Patte, MD · Gustave Roussy, Cancer Campus, Grand Paris

• Mary P. Gerrard, MBChB, FRCP, FRCPCH · Children's Hospital - Sheffield

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Eligibility

Max Age

20 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2001-06-30

Primary Completion

2003-10-31

Completion

2009-10-31

Countries

• France
• United Kingdom

Study Locations