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Improvement in Hepatic Function Through Sumac (Rhus Coriaria L.) Supplement Along With a Calorie-restricted Diet for the Management of Grade-I Obese Non-alcoholic Fatty Liver Disease Patients

NCT07768657 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 102

Last updated 2026-08-17

No results posted yet for this study

Summary

This randomized controlled trial aims to evaluate the effects of Rhus coriaria L. (Sumac) supplementation combined with a calorie-restricted diet on hepatic function and metabolic health in grade-I obese patients with non-alcoholic fatty liver disease (NAFLD). A total of 102 participants aged 30-60 years with confirmed NAFLD will be randomly assigned to one of three groups: placebo, 1.5 g/day Sumac supplementation, or 3.0 g/day Sumac supplementation for 12 weeks. Outcomes will include changes in liver function tests (ALT, AST, and ALP), anthropometric measurements, glycemic control, insulin resistance, lipid profile, and inflammatory biomarkers. The study aims to determine whether Sumac supplementation provides additional benefits beyond calorie restriction alone in improving hepatic health and metabolic risk factors associated with NAFLD.

Conditions

  • Liver Biomarkers
  • Lipid Profile
  • Glucose
  • Insulin

Interventions

DIETARY_SUPPLEMENT

T1 SUMAC SUPPLEMENT

T₁ received 1.5 g/day of Sumac supplementation with a calorie-restricted diet (1250-1300 kcal/day)

DIETARY_SUPPLEMENT

T2 SUMAC SUPPLEMENT

T₂ received 3.0 g/day of Sumac supplementation with the same calorie-restricted diet for 12 weeks

DIETARY_SUPPLEMENT

Placebo (Starch Capsule)

One starch capsule administered daily for 12 weeks.

Sponsors & Collaborators

  • University of Lahore

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-05
Primary Completion
2025-09-15
Completion
2025-09-16

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07768657 on ClinicalTrials.gov