Effect of Lysine and Phosphorus Fortification on Glycemic Index and Postprandial Glycemia in Double Fortified Bread

Summary

The goal of this clinical trial is to investigate the effect of lysine and phosphorous on the glycemic index (GI) of white bread and postprandial glycemia. The main questions it aims to answer are:

* Can double fortification with lysine and phosphorous lower the glycemic index (GI) of bread?
* Does double fortification with lysine and phosphorous improve postprandial glycemia?

Participants in the study will be assigned to the control group, where they will consume regular white bread, then to the experimental group, where they will consume double fortified bread with lysine and phosphorous. The glycemic response of the bread samples will be measured by monitoring blood glucose levels in healthy participants after consuming the bread. The glycemic index will also be calculated based on the area under the curve (AUC) of the test food compared to a standard. The collected data will be analyzed using statistical methods such as paired sample t-tests and one-way ANOVA.

The expected outcomes of the study are that lysine and phosphorous will reduce the glycemic index of white bread and also decrease the postprandial blood glucose spike. This research aims to provide valuable insights into fortifying bread to improve its health impact, particularly for individuals with diabetes or at risk of developing diabetes

Conditions

• Hyperglycemia
• Glucose Metabolism Disorders
• Metabolic Disease
• Glycemic Index

Interventions

DIETARY_SUPPLEMENT

Control Group - Standard White Bread

Participants consume commercially available standard white bread, serving as the control intervention.

DIETARY_SUPPLEMENT

Lysine Group - Lysine-Fortified Bread

Participants consume bread fortified with lysine, an essential amino acid, in a specified dosage, frequency, and duration.

DIETARY_SUPPLEMENT

Phosphorus Group - Phosphorus-Fortified Bread

Participants consume bread fortified with phosphorus, an essential mineral, in a specified dosage, frequency, and duration

DIETARY_SUPPLEMENT

Lysine and Phosphorus Group - Double Fortified Bread

Double Fortified Bread: Participants consume bread fortified with both lysine and phosphorus in specified dosages, frequencies, and durations.

Sponsors & Collaborators

• University of Veterinary and Animal Sciences, Lahore - Pakistan

  lead OTHER

Principal Investigators

• Mah Noor, MPhil · University of Veterinary and Animal Sciences, Lahore

Study Design

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

35 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-11-13

Primary Completion

2023-12-30

Completion

2024-01-31

Countries

• Pakistan

Study Locations