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Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults

NCT07649005 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-06-15

No results posted yet for this study

Summary

The goal of this clinical trial is to determine if a high potassium intake can counteract the harmful effects of excess sodium on endothelial function in older adults with no history of cardiometabolic disease. The main questions it aims to answer are:

1. Can a high potassium intake attenuate dietary sodium-induced endothelial dysfunction in older adults.
2. Do changes in endothelial function in response to alterations in sodium and potassium intake differ by sex.

Participants will participants will consume three controlled diets for 10 days each with a minimum 14-day washout between interventions. The order in which participants consume the diets will be randomized. The study diets will vary in sodium and potassium content. Measures of cardiovascular health (blood pressure, arterial stiffness, endothelial function) will be assessed at the end of each diet.

Conditions

  • Healthy Older Adults

Interventions

OTHER

low sodium/low potassium diet

On this intervention, participants will be given a diet that provides 2,000 mg Na/day and 2,000 mg K/day

OTHER

high sodium/low potassium diet

On this intervention, participants will be given a diet that provides 4,700 mg Na/day and 2,000 mg K/day

OTHER

high sodium/high potassium diet

On this intervention, participants will be given a diet that provides 4,700 mg Na/day and 4,700 mg K/day

Sponsors & Collaborators

Principal Investigators

  • Andrea Lobene · Florida State University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
55 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-24
Primary Completion
2027-06-30
Completion
2027-06-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07649005 on ClinicalTrials.gov