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Effect of Viscous Fiber on Postprandial Kalemic Response in Hemodialysis Patients

NCT05086185 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 7

Last updated 2025-03-27

No results posted yet for this study

Summary

High blood potassium levels (hyperkalemia) is a major problem for people with kidney failure undergoing hemodialysis treatment. In order to reduce the risk of hyperkalemia, people with kidney failure are advised to limit or avoid high-potassium foods. However, high-potassium foods comprise many healthy food choices, including commonly consumed fruits and vegetables that are key sources of dietary fiber, and other important nutrients.

Risk of hyperkalemia from dietary potassium intake is most notable in the first few hours after a meal when ingested potassium enters the bloodstream. In general, dietary potassium is very well absorbed. However, dietary fiber has been shown to increase the proportion of dietary potassium that is excreted in stool. Based on these findings, it has been proposed that fiber may help to lower the risk of hyperkalemia in people with kidney disease. It remains unclear whether dietary fiber increases potassium excretion in stool by reducing the absorption of dietary potassium, or by drawing body potassium into the bowels by increasing stool bulk. The distinction may be important, as reducing potassium absorption would be expected to be of greater benefit in preventing hyperkalemia caused by eating high-potassium foods.

In this study, the investigators will assess whether a fiber supplement can reduce the effect of dietary potassium from orange juice on blood potassium levels in people with kidney disease undergoing maintenance hemodialysis treatment.

Conditions

  • Hyperkalemia
  • Chronic Kidney Disease Requiring Chronic Dialysis

Interventions

DIAGNOSTIC_TEST

Kalemic Response to Orange Juice

100% pulp-free orange juice

DIETARY_SUPPLEMENT

Kalemic Response to Orange Juice with Fiber

100% pulp-free orange juice with psyllium-based fiber added

Sponsors & Collaborators

  • United States Department of Agriculture (USDA)

    collaborator FED

  • Sierra Nevada Nephrology Consultants, Inc.

    collaborator UNKNOWN

  • University of Nevada, Reno

    lead OTHER

Principal Investigators

  • David E St-jules, PhD · University of Nevada, Reno

Eligibility

Min Age
18 Years
Max Age
89 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-29
Primary Completion
2023-10-05
Completion
2023-10-05

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05086185 on ClinicalTrials.gov