Explorative Study to Investigate the Acid-base Response to Sodium and Potassium Salts in Patients With Chronic Kidney Disease.

Summary

With this research the investigators want to study how patients with chronic kidney disease respond to different sodium- and potassium salts. Potassium salts can prevent kidney damage and cardiovascular disease, however patients with chronic kidney disease can responds differently. Extra potassium can increase the amount of potassium in the blood and extra chloride can cause acidosis. With this study the investigators will gain more insight in how patients with chronic kidney disease respond to sodium and potassium salts and which one is more favorable.This information can then be used to guide the application of salt substitutes and dietary adjustments in patients with chronic kidney disease.

Conditions

• Metabolic Acidosis
• CKD
• Electrolyte and Fluid Balance Conditions

Interventions

DIETARY_SUPPLEMENT

Dietary supplement consisting of 40 mmol/daily of potassium chloride

The supplements are delivered in plain vegetable 00 caps, stabelizing additives are potatostarch, sunflower lecithine and sunflower oil. The capsuels are free of titanium oxide and suited for human consumption.

DIETARY_SUPPLEMENT

Dietary supplement consisting of 40 mmol/daily of potassium gluconate

The supplements are delivered in plain vegetable 00 caps, stabelizing additives are potatostarch, sunflower lecithine and sunflower oil. The capsuels are free of titanium oxide and suited for human consumption.

DIETARY_SUPPLEMENT

Dietary supplement consisting of 40 mmol/daily of potassium bicarbonate

The supplements are delivered in plain vegetable 00 caps, stabelizing additives are potatostarch, sunflower lecithine and sunflower oil. The capsuels are free of titanium oxide and suited for human consumption.

DIETARY_SUPPLEMENT

Dietary supplement consisting of 40 mmol/daily of sodium chloride

The supplements are delivered in plain vegetable 00 caps, stabelizing additives are potatostarch, sunflower lecithine and sunflower oil. The capsuels are free of titanium oxide and suited for human consumption.

DIETARY_SUPPLEMENT

Dietary supplement consisting of 40 mmol/daily of sodium bicarbonate

The supplements are delivered in plain vegetable 00 caps, stabelizing additives are potatostarch, sunflower lecithine and sunflower oil. The capsuels are free of titanium oxide and suited for human consumption.

DIETARY_SUPPLEMENT

Placebo caps

The supplements are delivered in plain vegetable 00 caps, stabelizing additives are potatostarch, sunflower lecithine and sunflower oil. The capsuels are free of titanium oxide and suited for human consumption.

Sponsors & Collaborators

• Erasmus Medical Center

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-01-26

Primary Completion

2025-03-21

Completion

2026-07-31

Countries

• Netherlands

Study Locations