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Effect of a High-Protein Diet With Meal Replacements on Weight Loss

NCT07547722 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-05-06

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if a structured high-protein diet with meal replacements can help with weight loss in adults with overweight or obesity. The main questions it aims to answer are:

Does this diet help participants lose more body weight? Does this diet improve body composition and blood markers such as glucose and cholesterol?

Researchers will compare a structured diet program with meal replacements to a standard low-calorie diet to see if it leads to better weight loss and health outcomes.

Participants will:

Follow a calorie-restricted diet for the duration of the study Be assigned to either a meal replacement program or a standard diet Attend study visits for body measurements and blood tests Report their feelings of hunger and fullness

Conditions

  • Obesity & Overweight

Interventions

DIETARY_SUPPLEMENT

Meal Replacement and Dietary Supplementation

Participants replace two main meals per day with a protein-based meal replacement shake and take additional dietary supplements in capsule form twice daily with snacks as part of a structured, calorie-restricted diet. Participants also follow individualized meal plans tailored to their caloric needs.

BEHAVIORAL

Calorie-Restricted Diet

Participants follow a standard calorie-restricted diet based on general nutritional recommendations without meal replacement products or additional dietary supplements. Participants also follow individualized meal plans tailored to their caloric needs.

Sponsors & Collaborators

  • Kazakh Academy of Nutrition

    lead OTHER

Principal Investigators

  • Aliya Kaldybai · Kazakh Academy of Nutrition, Almaty, Kazakhstan

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-01
Primary Completion
2026-07-31
Completion
2026-07-31

Countries

  • Kazakhstan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07547722 on ClinicalTrials.gov