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Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis

NCT07547202 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2026-04-23

No results posted yet for this study

Summary

This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis. Periodontitis is a chronic inflammatory disease that destroys tooth-supporting tissues. Smoking is a significant risk factor that worsens periodontal destruction and reduces the effectiveness of standard therapies.

* The trial is a non-randomized comparative clinical study.
* It includes 44 adult patients diagnosed with Stage II and III periodontitis.
* The participants are divided into two equal groups: 22 current smokers and 22 non-smokers.
* Participants will undergo a baseline examination, followed by standardized non-surgical periodontal therapy consisting of scaling and root planing.
* A follow-up visit will be conducted six weeks post-therapy to repeat clinical measurements and saliva collection.
* The primary objective is to evaluate changes in salivary biomarker levels and clinical parameters (Plaque Index, Gingival Index, bleeding on probing, Probing Pocket Depth, Clinical Attachment Level) after treatment.

Conditions

  • Periodontitis
  • Smoking ( Cigarette)

Interventions

PROCEDURE

Non-surgical periodontal therapy (Scaling and root planing)

Standardized non-surgical periodontal therapy performed over two visits (scaling at the first visit and root planing after one week).

Sponsors & Collaborators

  • Al-Mustansiriyah University

    lead OTHER

Principal Investigators

  • Hussein Abdul-Rassul Hatiem, B.D.S., M.Sc. Student · College of Dentistry / Mustansiriyah University

  • Ghasaq Asim Abdulwahab, B.D.S., M.Sc., Ph.D. · College of Dentistry / Mustansiriyah University

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-01
Primary Completion
2026-08-01
Completion
2026-10-01

Countries

  • Iraq

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07547202 on ClinicalTrials.gov