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The Effect of Non-Surgical Periodontal Treatment on Systemic Inflammatory Markers and Lipid Profile in Young Adults With Severe Periodontitis

NCT07526883 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-04-13

No results posted yet for this study

Summary

The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis. The main questions it aimed to answer were:

Did non-surgical periodontal treatment improve gum health in young adults with severe periodontitis?

Did non-surgical periodontal treatment change body-wide inflammation and blood fat levels after treatment?

Researchers compared participants with severe periodontitis to healthy participants without periodontitis.

Participants with severe periodontitis:

* Received oral hygiene instructions, deep cleaning below the gumline, root surface cleaning, and removal of teeth that could not be saved
* Had full-mouth gum examinations
* Provided blood samples at the start of the study and again at 2 and 6 months after treatment

Healthy participants:

* Had gum examinations
* Provided blood samples for comparison at the start of the study

Conditions

  • Periodontitis, Aggressive

Interventions

PROCEDURE

Non-surgical periodontal treatment

Non-surgical periodontal treatment consisted of oral hygiene instruction, subgingival scaling, root planing, and extraction of unsalvageable teeth under local anesthesia. Treatment was completed within 1 week. Clinical periodontal measurements and blood samples were obtained at baseline and repeated at 2 and 6 months after completion of treatment.

Sponsors & Collaborators

  • Istanbul University

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Max Age
36 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-07-01
Primary Completion
2009-12-01
Completion
2010-06-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07526883 on ClinicalTrials.gov