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Serum Inflammatory Protein Concentration During Dental Treatment

NCT07468929 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2026-04-20

No results posted yet for this study

Summary

The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery. The main question it aims to answer are:

* How do the levels of inflammatory molecules in the blood change during a periodontal surgery?
* How are the levels of inflammatory molecules in a person having surgery different from the levels in a person having a nonsurgical procedure?
* Participants will be people who are having a periodontal surgery or a nonsurgical periodontal treatment as part of their dental care. Participants will be asked to let the investigator take blood samples from them before, during, and after the procedure is being done. The blood will later be analyzed for substances in the blood that are associated with inflammation.

Conditions

  • Periodontal Disease
  • Periodontal Surgery

Interventions

OTHER

Blood samples for inflammatory markers

Blood samples will be obtained before the start of the procedure, the midpoint of the procedure, and the end of the procedure.

PROCEDURE

periodontal surgery

Periodontal/peri-implant surgical interventions, with or without IV sedation, as based on treatment needs

PROCEDURE

Periodontal maintenance

Regular cleaning to maintain health after surgical treatment for periodontal disease

PROCEDURE

Non-surgical deep cleaning

Debridement under local anesthesia, as based on treatment needs

Sponsors & Collaborators

  • Ohio State University

    lead OTHER

Principal Investigators

  • Binnaz Leblebibioglu, DDS, MS, PhD · Ohio State University

Eligibility

Min Age
21 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-31
Primary Completion
2027-02-28
Completion
2027-02-28

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07468929 on ClinicalTrials.gov