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Periodontal Status and Cytokine Levels in Patients With Non-Infectious Uveitis

NCT07480291 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 52

Last updated 2026-03-18

No results posted yet for this study

Summary

This cross-sectional observational study aimed to evaluate periodontal clinical parameters and inflammatory cytokine levels in gingival crevicular fluid (GCF), saliva, and serum in patients with non-infectious uveitis (NIU) compared with systemically healthy individuals.

Twenty-five patients diagnosed with non-infectious uveitis and twenty-seven age- and sex-matched healthy controls were included. Clinical periodontal parameters including probing pocket depth, clinical attachment loss, plaque index, gingival index, and bleeding on probing were recorded. Biological samples including saliva, gingival crevicular fluid, and serum were collected.

Levels of TNF-α, IL-1β, IL-2, IL-6, IL-8, IL-10, and IL-17 were measured using ELISA. The study aimed to investigate whether periodontal inflammatory status and systemic cytokine profiles are associated with non-infectious uveitis.

Conditions

  • Non-infectious Uveitis
  • Periodontal Disease

Sponsors & Collaborators

  • Selcuk University

    lead OTHER

Principal Investigators

  • Duygu durmaz, DDS,MSc · Pendik Oral and Dental Health Hospital, Istanbul, Turkey

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-10-01
Primary Completion
2021-08-31
Completion
2021-08-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07480291 on ClinicalTrials.gov