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Wildfire Related Air Pollution Exposure and Cognitive Function Pilot Study

NCT07151235 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2025-12-02

No results posted yet for this study

Summary

This study will examine how breathing wildfire-related air pollution (WRAP) for one hour affects healthy adults. The main question the study will answer if the effect of WRAP exposure on p-tau, a blood marker of cognitive decline. The changes in p-tau concentrations after exposure to WRAP will be compared to the changes in p-tau after exposure to clean air.

Participants will:

* Have 2 study visits - one visit with exposure to clean air and one visit with exposure to simulated wildfire smoke
* Have blood drawn before and after each exposure
* Complete cognitive tests and memory tasks before and after each exposure

Conditions

  • Healthy Participants

Interventions

OTHER

Simulated wildfire smoke exposure

1 hour exposure to simulated wildfire smoke (300 ug/m3 PM)

OTHER

Clean Air exposure

1 hour exposure to clean (HEPA-filtered) air (0 ug/m3 PM)

Sponsors & Collaborators

  • Rutgers, The State University of New Jersey

    lead OTHER

Principal Investigators

  • Jose G Cedeno-Laurent, ScD · Rutgers, The State University of New Jersey: New Brunswick/Piscataway Campus

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-18
Primary Completion
2025-11-20
Completion
2025-11-20

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07151235 on ClinicalTrials.gov