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Modification of Ambient Air Pollution Exposure and Cardiopulmonary Outcomes by Socioeconomic Status and Nutrition

NCT05843370 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 82

Last updated 2024-02-20

No results posted yet for this study

Summary

The goal of this observational study is to compare the effects of air pollution exposure and nutrition between neighborhoods with high and low social vulnerability scores. The main questions this study aims to answer are:

* Does living in a neighborhood with high or low vulnerability influence the response of the heart, lungs, and immune system to air pollution.
* Does nutritional status alter the association between air pollution exposure and changes in the heart, lungs, and immune system.

Participants (age 25-70 years) that live in neighborhoods ranked high or low on the Social Vulnerability Index (SVI) will take part in 3 visits. Each visit involves the following:

* Measurements of heart activity, lung function, and blood to measure changes that may be caused by air pollution.
* Questionnaires about the types of food eaten and activities that may modify exposure to air pollution.
* Estimation of air pollution exposure using a study iPhone. Participants will carry a study iPhone with them for 24 hours at each visit. The study iPhone runs an application (app) that estimates the amount of air pollution each participant is exposed to.
* Wearing silicone wristbands for a week before each study visit. Silicone wristbands absorb air pollutants and are later measured see the types and amounts of chemicals participants are exposed to.

Conditions

  • Air Pollution
  • Pollution; Exposure
  • Nutrition, Healthy

Sponsors & Collaborators

  • Environmental Protection Agency (EPA)

    lead FED

Eligibility

Min Age
25 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-08-21
Primary Completion
2025-12-31
Completion
2027-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05843370 on ClinicalTrials.gov