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Effects of Air Pollution Exposure Reduction by Filter Mask on Heart Failure

NCT01960920 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2015-08-25

No results posted yet for this study

Summary

Exposure to air pollution is associated with increase in cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular function and heart rate variability on healthy volunteers. The aim of this study is to investigate the effects of reducting diesel exhaust inhalation on endothelial function, heart rate variability and cardiopulmonary stress testing in healthy volunteers and patients with chronic heart failure, by using a filter mask.

Conditions

Interventions

OTHER

Filtered diesel exhaust

Mask-filtered exposure to diesel exhaust

OTHER

Unfiltered diesel exhaust

Diesel Exhaust Inhalation

OTHER

Clean air

No pollution and no filter mask

Sponsors & Collaborators

  • Fundação de Amparo à Pesquisa do Estado de São Paulo

    collaborator OTHER_GOV

  • LABORATÓRIO DE INSUFICIÊNCIA CARDÍACA E TRANSPLANTE INCOR/HCFMUSP

    collaborator UNKNOWN

  • LABORATÓRIO DE POLUIÇÃO ATMOSFÉRICA EXPERIMENTAL (LPAE/ FMUSP).

    collaborator UNKNOWN

  • InCor Heart Institute

    lead OTHER

Principal Investigators

  • Edimar A Bocchi, pHD · Heart Failure Lab. Coordinator

Study Design

Allocation
RANDOMIZED
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2014-06-30
Completion
2015-01-31

Countries

  • Brazil

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01960920 on ClinicalTrials.gov