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Impact of Telomere Biology and Sperm DNA Fragmentation on Embryonic Development

NCT05508217 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 204

Last updated 2024-01-11

No results posted yet for this study

Summary

The proposed project we intend to assess the implication of the telomeric pathway in male infertility. To get this, several analyzes will be carried out: 1. Determination of the TL by means of two methods: Q-FISH and PCR. 2. Determination of sperm DNA fragmentation by tunnel technique. 3. Assess sperm maturation.

Finally, the correlations between age, normality or not of the seminogram, LT, Short telomers (ST) accumulation, DNA fragmentation levels, sperm maturation and fertility, blastocyst development, and pregnancy rates will be established in search of cut-off points that can give a forecast of man´s fertility who consults on this subject.

Conditions

  • Sperm DNA Fragmentation
  • Male Fertility
  • Telomeres
  • Sperm

Sponsors & Collaborators

  • IVI Madrid

    lead OTHER

Principal Investigators

  • Carlos Balmori Boticario, PhD · IVI Madrid

Eligibility

Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-08-22
Primary Completion
2024-10-01
Completion
2024-12-01

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05508217 on ClinicalTrials.gov