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Pain Perception and the Autonomic Nervous System

NCT06667895 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 146

Last updated 2024-10-31

No results posted yet for this study

Summary

In this study, we want to investigate how pain processing and sensation are related to a certain part of the nervous system, the so-called autonomic nervous system.

For this purpose, we apply heat and pressure stimuli to the skin and test pain processing by means of ratings scales and sensory tests. Breathing, heart rate and sweat response are also measured. To assess the spinal cord level, we measure muscle response (measured by electromyography, EMG) to electrical stimulation. Additionally, sensory nerves will be stimulated at the ear and participants will also be given various questionnaires to complete.

Conditions

  • Autonomic Nervous System Modulation
  • Pain Perception
  • Pain Sensitivity
  • Central Sensitization
  • Vagus Nerve Stimulations

Interventions

OTHER

respiratory gated taVNS

Electrical stimulation will be delivered in bursts during expiration

OTHER

random burst stimulation

Electrical stimulation will be delivered in bursts at random timepoints during the breathing cycle

OTHER

continuous stimulation

Electrical stimulation will be delivered continuously for 30sec followed by a 30sec break.

OTHER

Sham stimulation

Electrical stimulation will be identical to the taVNS, but the electrodes will be placed at a different position on the ear

Sponsors & Collaborators

  • Schweinhardt Petra

    lead OTHER

Principal Investigators

  • Petra Schweinhardt, PhD, M Chiro Med · Balgrist University Hospital, University of Zurich, Zurich, Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-11-04
Primary Completion
2026-08-31
Completion
2026-08-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06667895 on ClinicalTrials.gov