MedTrace Logo

Pain Modulation - Experimental Assessments Using Different Modalities

NCT04323293 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 705

Last updated 2023-04-14

No results posted yet for this study

Summary

The goal of this study is to investigate how different painful stimuli are processed and modulated in the nervous system. In various pain conditions, including low back pain, often no specific source can be identified as the cause of the pain. Scientific findings point towards a possible involvement of sensitization processes in the central nervous system (spinal cord and brain) that can contribute to the development and persistence of chronic pain. There is a need for reliable and well established experimental methods to better investigate and understand these processes. Frequently used methods comprise the application of thermal, mechanical or electrical stimulations. These modalities are processed in different parts of the nervous system, each allowing its own conclusions. This can be an advantage, but it also poses a challenge regarding comparability and generalizability of obtained results.

This study aims to apply and compare various experimental methods in people without and people with low back pain and shed light on the methodological differences. In the future, this could enable better identification and characterization of sensitization processes in the nervous system and build the basis for individually adapted, mechanism-targeted treatments with better patient outcomes.

Conditions

  • Low Back Pain
  • Compare Pain Modulation Assessments in Pain-free Cohorts

Interventions

OTHER

Cold Water Bath

immersion of the hand for 2-5min in 2-10°C water

OTHER

Neutral Water Bath

immersion of the hand for 2-5min in 32±2°C water

Sponsors & Collaborators

  • Schweinhardt Petra

    lead OTHER

Principal Investigators

  • Petra Schweinhardt, PhD · Integrative Spinal Research, Department of Chiropractic Medicine, Balgrist University Hospital, University of Zurich

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-05-01
Primary Completion
2025-05-31
Completion
2025-05-31

Countries

  • Switzerland

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04323293 on ClinicalTrials.gov