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Pain Processing In Relation To Breathing

NCT06169917 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2023-12-14

No results posted yet for this study

Summary

The goal of this clinical trial is to investigate the effect of breathing on the processing of experimental pain in healthy participants. The main questions are:

1. Does breathing rate influence the spatial extent of thermally induced secondary hyperalgesia, a proxy of central sensitization?
2. Does resonance frequency breathing influence the autonomic nervous system, compared to baseline and compared to paced breathing at a natural frequency?
3. Is spinal excitability, measured using the magnitude of the nociception withdrawal reflex (NWR), affected by resonance frequency breathing, compared to paced breathing at a natural frequency?

Participants:

* will receive heat stimuli
* 's skin's sensitivity will be tested using quantitative sensory testing tools.
* will receive various instructions on the speed of their breathing
* 's heart rate, respiratory rate and sweat response will be measured
* will fill in questionnaires

Researchers will compare the spatial extent of sensitivity resulting from application of heat stimuli during paced resonance frequency breathing compared to paced breathing at a natural frequency to see if the breathing rhythm influences central sensitization processes.

Conditions

  • Central Sensitisation
  • Pain

Interventions

BEHAVIORAL

Paced Resonance Frequency Breathing

Participants are required to pace their breathing to their pre-determined individual resonance frequency.

BEHAVIORAL

Paced Breathing at Natural Frequency

Participants are required to pace their breathing to their pre-determined individual breathing frequency at rest.

OTHER

Heat Stimulations

Participants will undergo a heat stimulation procedure on their left and right foot (the order of which is counterbalanced across participants). During this procedure, there are 10 blocks, with an inter-stimulus interval of 30 seconds between two blocks. During a block, six 6-second heat stimulations (48 degrees) are given. Between the stimulations, the temperature quickly returns to baseline (32 degrees).

Sponsors & Collaborators

  • Balgrist University Hospital

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-05-14
Primary Completion
2025-05-31
Completion
2025-05-31

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06169917 on ClinicalTrials.gov