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A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing

NCT03576053 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 59

Last updated 2020-07-08

No results posted yet for this study

Summary

The purpose of this human experimental study is to evaluate the pattern of itch intensity over time in response to strong, short-term heat stimulation in two different models of histamine and cowhage-induced itch. Moreover, the purpose is to evaluate the effect of mild pre-heating of the skin in human experimental models of histamine, cowhage and serotonin. Finally, we want to investigate the effect of short-term intense heat stimulation on previously anesthetized skin.

Conditions

  • Itch
  • Thermal Stimulation
  • Histamine
  • Cowhage
  • Serotonine

Interventions

DRUG

Lidocaine

Lidocaine intradermal injection

OTHER

Histamine

Skin Prick Test with Histamine

OTHER

Cowhage

Manually skin insertion of cowhage spicules

OTHER

Heat stimulation

Short heat stimulation

OTHER

Pre-heating

Mild skin pre-heating

OTHER

Serotonin

Serotonin electrophoresis

Sponsors & Collaborators

  • Aalborg University

    lead OTHER

Principal Investigators

  • Daniele Riccio, MSc · Aalborg University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-07-01
Primary Completion
2019-07-31
Completion
2019-08-28

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03576053 on ClinicalTrials.gov