MedTrace Logo

Central Sensitisation in Nociceptive and Neuropathic Pain

NCT07321080 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 185

Last updated 2026-04-20

No results posted yet for this study

Summary

This study aims to investigate differences in central sensitization among patients with chronic nociceptive pain, neuropathic pain, and mixed pain conditions. Chronic pain is a complex and multidimensional phenomenon involving sensory, cognitive, emotional, and behavioral components, often sustained by mechanisms of central sensitization that contribute to pain persistence and treatment resistance.

Using a multidimensional assessment approach, the study integrates self-report questionnaires, neuropsychological evaluation, psychological measures, treatment adherence assessment, and neurophysiological investigation through laser-evoked potentials (LEP). Participants will be evaluated at baseline and after 12 months to explore differences between pain types and longitudinal changes in central sensitization, cognitive functioning, emotional status, and engagement with treatment.

The findings are expected to improve the understanding of neurobiological and psychosocial mechanisms underlying different chronic pain phenotypes and to support more personalized and effective pain management strategies.

Conditions

  • Chronic Pain
  • Nociceptive Pain
  • Neuropathic Pain
  • Mixed Pain (Nociceptive and Neuropathic)

Interventions

BEHAVIORAL

Neuropsychological assessment

Neuropsychological assessment Standardized and ad hoc test battery for comprehensive neuropsychological assessment

BEHAVIORAL

Laser evoked potentials

Laser evoked potentials

Sponsors & Collaborators

  • IRCCS Centro Neurolesi Bonino Pulejo

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-15
Primary Completion
2027-12-15
Completion
2027-12-20

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07321080 on ClinicalTrials.gov