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Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8

NCT05935280 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2024-03-15

No results posted yet for this study

Summary

Animal studies suggest that the transient receptor potential ion channels TRPM8 and TRPA1 are cold sensors and that sodium channels Nav1.8 and Nav1.7 are essential for detecting pain induced by cold temperatures. This study aims to validate these findings in humans.

Conditions

Interventions

OTHER

Room temperature

Room temperature injection

OTHER

Cold temperature

Cold temperature injection

DRUG

Lidocain

Unspecific sodium channel blocker

DRUG

PF-05105679

Specific antagonist of the TRPM8 ion channel

DRUG

A967079

Specific antagonist of the TRPA1 ion channel

DRUG

PF-05089771

Specific antagonist of the Nav1.7 sodium channel

DRUG

PF-06305591

Specific antagonist of the Nav1.8 sodium channel

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Michael JM Fischer · Medical University of Vienna

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-07-07
Primary Completion
2023-09-01
Completion
2023-09-01

Countries

  • Austria

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05935280 on ClinicalTrials.gov