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Effect of Protein on Endoplasmic Reticulum Stress

NCT06621901 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2024-10-01

No results posted yet for this study

Summary

This study was planned to provide information about the effect of short-term high protein diet (HPD) feeding on endoplasmic reticulum stress. The definition of HPDs cannot be determined exactly. They are defined differently by various scientific authorities. However, the target is for protein to be approximately 30% of total energy in HPD. It has been determined that HPDs increase satiety, thermogenesis, and provide body weight loss and maintenance of loss. In general, there is evidence that HPDs provide more body weight loss in a short time compared to low protein diets. It has been emphasized that the effect of high protein diet on weight loss is related to creating satiety, thus reducing food intake and increasing thermogenesis. However, the physiological, biochemical and molecular events that occur due to HPD feeding are not fully understood and the results have not been explained. It has been determined that the effects of HPDs last between 1 and 6 days and 6 months. The absence of any study in the literature on the short-term and long-term effects of HPD on oxidative events in humans reveals the original value of this study. Therefore, considering that long-term HPD feeding may increase the risk of cardiovascular disease, blood pressure and blood lipid levels, the effect of short-term HPD feeding on endoplasmic reticulum stress will be investigated in order to avoid these side effects. Blood analyses planned for this prospective analytical study will be performed in GENKÖK Laboratory. Healthy individuals will be administered 10 days of HPD and a 10-day normal diet as a control.

Conditions

  • Effect of High Protein Diet on Endoplasmic Reticulum Stress

Interventions

OTHER

High Protein Diet

Individuals will be placed on a high protein diet for 10 days.

OTHER

Normal Protein Diet

Individuals will be placed on a normal protein diet for 10 days.

Sponsors & Collaborators

  • The Scientific and Technological Research Council of Turkey

    collaborator OTHER

  • TC Erciyes University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-10-01
Primary Completion
2025-10-01
Completion
2025-10-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06621901 on ClinicalTrials.gov