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The Effects of Dietary Fibres on Metabolic Health and the Gut Microbiome

NCT06580132 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2024-08-30

No results posted yet for this study

Summary

The study involves intake of dietary supplements, which are commonly found in the UK diet (not pharmacological agents) to test their effects on inflammation in the body and gut microbiome composition. Study subjects will be healthy volunteers recruited from the University and local population and will be asked to attend the laboratory on 2 occasions; before and after 4-week' supplementing the diet daily with either the dietary fibres (the current trial focussed on pectin) or placebo (maltodextrin). At each study visit (\~3hrs), participants will be asked to provide a stool and blood sample and will have blood pressure measured. In the week before each study visit, participants will record their food intake.

Conditions

  • Diet
  • Healthy
  • Systemic Inflammatory Response

Interventions

DIETARY_SUPPLEMENT

Pectin

Pectin fibre (20g) was randomly allocated to eligible participants in order to test specific effects on gut microbiome composition and metabolic markers.

DIETARY_SUPPLEMENT

Maltodextrin

Maltodextrin (10g) served as a control/ placebo to compare the effects observed with pectin.

Sponsors & Collaborators

  • Elizabeth Simpson

    lead OTHER

Principal Investigators

  • Ana Valdes, Professor · University of Nottingham

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-09-09
Primary Completion
2022-09-09
Completion
2022-09-09

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06580132 on ClinicalTrials.gov