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ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study

NCT06370845 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2026-05-04

No results posted yet for this study

Summary

The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.

Conditions

  • Overweight and Obesity

Interventions

COMBINATION_PRODUCT

Inhalation - Natural Odour

Inhalation of 50 uL of a natural odour via nasal septum mini-inhaler.

COMBINATION_PRODUCT

Inhalation - Placebo

Inhalation of 50 uL of Placebo via nasal septum mini-inhaler.

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Katharina Timper, Prof. Dr. med. · University Hospital Basel, Department of Endocrinology, Diabetology and Metabolism

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-14
Primary Completion
2027-08-31
Completion
2027-10-30

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06370845 on ClinicalTrials.gov