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Cough Responses to Tussive Agents in Health and Disease

NCT01297790 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 102

Last updated 2011-09-16

No results posted yet for this study

Summary

The sensitivity of a persons cough reflex can be measured by getting them to breath in (inhale) irritant chemicals. The purpose of this clinical research study is to test the sensitivity of the cough reflex to a variety of chemicals that can be inhaled to see if coughing responses are different between healthy people and people with respiratory problems that make them cough.

Conditions

  • Chronic Obstructive Airway Disease
  • Asthma
  • Chronic Cough

Interventions

OTHER

Cough Challenge Tests

Inhalational cough challenge tests with capsaicin, bradykinin, Citric acid and prostaglandin E2

OTHER

ambulatory cough recording

Cough recording with a portable device to capture cough sounds

OTHER

Cough questionnaires

Questionnaires designed to study cough. These include Leicester cough questionnaire, cough visual analogue score and cough quality of life questionnaire.

Sponsors & Collaborators

  • Manchester University NHS Foundation Trust

    lead OTHER_GOV

Principal Investigators

  • Ashley A Woodcock, FRCP, MD · University Hospital of South Manchester

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-11-30
Primary Completion
2011-05-31
Completion
2011-05-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01297790 on ClinicalTrials.gov