Influence of a Mediterranean Diet Combined With a Physical Activity Intervention, on NAFLD and Inflammation Parameters.

Summary

The study in question is an interventional study with nutritional intervention.

The aim of the study is to evaluate whether the adoption of two different models of Mediterranean Diet, based on the different percentage of carbohydrates and lipids, associated with a program of moderate intensity aerobic physical exercise, in patients with obesity and NAFLD can exercise, after only 3 months, effects on:

* specific aspects associated with NAFLD, such as the degree of hepatic steatosis and fibrosis;
* circulating levels of molecules correlated with the degree of generalized and hepatic inflammation and the blood concentrations of metabolic and cardiovascular risk factors associated with abdominal obesity;
* intestinal barrier;
* body composition;
* intestinal microbiota;
* symptoms of IBS (irritable bowel syndrome) in patients with NAFLD.

Conditions

• NAFLD
• Obesity
• IBS

Interventions

OTHER

Mediterranean diet and moderate intensity physical exercise (outdoor walking).

Mediterranean Diet, based on the different percentage of carbohydrates and lipids, associated with a program of moderate intensity aerobic physical exercise (outdoor walking), in patients with obesity and NAFLD.

Sponsors & Collaborators

• Russo Francesco

  collaborator UNKNOWN

• Cozzolongo Raffaele

  collaborator UNKNOWN

• Shahini Endrit

  collaborator UNKNOWN

• Zappimbulso Marianna

  collaborator UNKNOWN

• Giannuzzi Vito

  collaborator UNKNOWN

• De Nucci Sara

  collaborator UNKNOWN

• Rinaldi Roberta

  collaborator UNKNOWN

• Sila Annamaria

  collaborator UNKNOWN

• Tatoli Rossella

  collaborator UNKNOWN

• Cerabino Nicole

  collaborator UNKNOWN

• Donghia Rossella

  collaborator UNKNOWN

• Franco Isabella

  collaborator UNKNOWN

• Bianco Antonella

  collaborator UNKNOWN

• Curci Ritanna

  collaborator UNKNOWN

• Bagnato Claudia Beatrice

  collaborator UNKNOWN

• Sciarra Sabrina

  collaborator UNKNOWN

• Prospero Laura

  collaborator UNKNOWN

• Serino Grazia

  collaborator UNKNOWN

• Scalavino Viviana

  collaborator UNKNOWN

• Piccinno Emanuele

  collaborator UNKNOWN

• Pesole Pasqua Letizia

  collaborator UNKNOWN

• Coletta Sergio

  collaborator UNKNOWN

• Stabile Dolores

  collaborator UNKNOWN

• Riezzo Giuseppe

  collaborator UNKNOWN

• Ancona Anna

  collaborator UNKNOWN

• D'Attoma Benedetta

  collaborator UNKNOWN

• Ignazzi Antonia

  collaborator UNKNOWN

• Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-03-19

Primary Completion

2025-04-08

Completion

2026-04-08

Countries

• Italy

Study Locations