The Effect of Exercise Intervention on Insulin Resistance in Non-alcoholic Fatty Liver Disease (NAFLD)

Summary

This project examines the effects of a 4 month structured exercise intervention program in patients with non-alcoholic fatty liver disease (NAFLD). We will examine changes in total and depot-specific (i.e.in different tissues, liver, muscle and pancreas)fat. We will correlate these with measurements of the insulin from the liver. The hypothesis is that by reducing fat in these specific depots we can reduce insulin resistance and prevent progression to diabetes.

Conditions

• Non Alcoholic Fatty Liver Disease

Interventions

BEHAVIORAL

Unsupervised exercise training

The patients will be given lecture on lifestyle changes and its benefitial effects on health at the begining of the study by the exercise trainer. There will be no conatct with the exercise trainer for the period of intervention for 4 months.

BEHAVIORAL

Supervised exercise training

Patients will be encouraged to exercise four times per week for 30-45 min at 60-80 % of maximal heart rate, with a 5 min warm-up and warm-down. Participants will be given free access to a variety of affiliated sports centres and will use the Wellness Key system, a software program that enables researchers to remotely track the exercise activity of participants very accurately. To ensure compliance with rest or exercise, all participants of both groups will have their mean physical activity level in 2 non-consecutive weeks evaluated with an ambulatory accelerometer.

Sponsors & Collaborators

• Royal Liverpool University Hospital

  collaborator OTHER_GOV

• University of Surrey

  collaborator OTHER

• Imperial College London

  collaborator OTHER

• Royal Surrey County Hospital NHS Foundation Trust

  collaborator OTHER

• University of Liverpool

  lead OTHER

Principal Investigators

• Daniel Cuthbertson, BSc PhD MRCP · University of Liverpool

• Fariba Shojaee-Moradie, BSc PhD · University of Surrey

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-01-01

Primary Completion

2013-04-01

Completion

2013-04-01

Countries

• United Kingdom

Study Locations