Monitoring of Hepatic Fat Metabolism Using Magnetic Resonance Methods

Summary

The first primary research objective of the study is to determine whether high-fat load (150 g of fat) induces increase in hepatic fat content (HFC) three and six hours after meal in insulin-sensitive subjects with normal HFC (\<5% of fat) and in non-diabetic subjects with an increased HFC (\>5% of fat). Furthermore, the other objective of the study is to determine whether the response of HFC to a high-fat load is affected by coadministration of glucose or fructose.

Conditions

• Hepatic Fat Content

Interventions

DIETARY_SUPPLEMENT

Fat

Subjects will consume dairy cream (150 g of fat) at time 0 hours.

DIETARY_SUPPLEMENT

Fasting

Subjects will fast throughout the experiment.

DIETARY_SUPPLEMENT

Fat+Glucose

Subjects will consume dairy cream (150 g of fat) at time 0 hours. At the same time and 2 and 4 hours later they will drink herbal tea containing 50 g of glucose.

DIETARY_SUPPLEMENT

Glucose

Subjects will drink herbal tea containing 50 g of glucose at times 0, 2 and 4 hours.

DIETARY_SUPPLEMENT

Fat+Fructose

Subjects will consume dairy cream (150 g of fat) at time 0 hours. At the same time and 2 and 4 hours later they will drink herbal tea containing 50 g of fructose.

DIETARY_SUPPLEMENT

Fructose

Subjects will drink herbal tea containing 50 g of fructose at times 0, 2 and 4 hours.

Sponsors & Collaborators

• Institute for Clinical and Experimental Medicine

  lead OTHER_GOV

Principal Investigators

• Milan Hajek, DSc · Institute for Clinical and Experimental Medicine

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-04-26

Primary Completion

2019-12-31

Completion

2019-12-31

Countries

• Czechia

Study Locations