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The Effect of a High-fat vs. High-sugar Diet on Liver Fat Accumulation and Metabolism

NCT03145350 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2020-03-27

No results posted yet for this study

Summary

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in the world. It is currently unclear why fat starts to accumulate in the liver, although both the amount and type of food consumed have been implicated. The majority of studies that have investigated the effects of dietary fat or sugar on liver fat have fed volunteers excess calories, which are known to increase liver fat. The effect of specific dietary components, when consumed as part of a diet not containing excess calories, on liver fat accumulation remains unclear.

Conditions

  • Fat; Liver
  • NAFLD

Interventions

OTHER

High-fat, low-carbohydrate

Dietary intervention: 4 week

OTHER

Low-fat, high-carbohydrate

Dietary intervention: 4 week

Sponsors & Collaborators

  • University of Oxford

    lead OTHER

Principal Investigators

  • Leanne Hodson, PhD · University of Oxford

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-12-31
Primary Completion
2019-12-31
Completion
2020-03-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03145350 on ClinicalTrials.gov