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Understanding the Role of Dietary Fatty Acids on Liver Fat Metabolism in Humans

NCT01936779 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2017-01-05

No results posted yet for this study

Summary

High levels of fatty substances in the blood increase the risk of developing heart disease. Investigators know a lot about one of these fatty substances, cholesterol. However, there is another fatty substance in the blood called triglyceride. Investigators do not understand much about what regulates the rate at which the liver produces triglyceride and liberates it into the bloodstream after eating a meal(s). It is known that taking fish oil lowers the amount of blood triglyceride however, it remains unclear how this happens. Investigators will study if changes in liver fat metabolism, after taking fatty acids found in fish oil (n-3 fatty acids)can explain the lowering of blood triglyceride. Investigators also want to know if taking fish oil alters the amount of fat that accumulates within the liver.

Conditions

  • NAFLD

Interventions

DIETARY_SUPPLEMENT

Dietary supplement: fatty acid

Consumption of n-3 fatty acids for 8 weeks

DIETARY_SUPPLEMENT

Dietary supplement: fatty acid

Consumption of olive oil for 8 weeks.

Sponsors & Collaborators

  • University of Oxford

    lead OTHER

Principal Investigators

  • Leanne Hodson, PhD · University of Oxford

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-09-30
Primary Completion
2016-04-30
Completion
2016-08-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01936779 on ClinicalTrials.gov