Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle

Summary

BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular properties and physical performance in healthy older men 60-75 years old.

Conditions

• Aging
• Cognitive Decline
• Sarcopenia
• Frailty
• Muscle Degeneration
• Physical Disability

Interventions

BEHAVIORAL

BFRT

Following a warm-up of 10 min, subjects in the experimental group will undergo BFRT for two times per week, consisting of lower extremity exercises (leg press, knee extension, knee flexion). BFRT will be at 40% of 1 repetition maximum (1RM); The volume % (V% = number of repetitions x number of sets x number of exercises x % 1 repetition max) = 57.6%. Progression during the 12 week program will be attained by a 1RM test every 4 weeks.

BEHAVIORAL

MDRT

Following a warm-up of 10 min, subjects in the experimental group will undergo MDRT for two times per week, consisting of lower extremity exercises (leg press, knee extension, knee flexion). The exercise will be at 80% of 1RM concentric-only or 120% of 1RM eccentric-only in a 3:1 ratio. The volume % (V% = number of repetitions x number of sets x number of exercises x % 1 repetition max) = 57.6%. Progression during the 12 week program will be attained by a 1RM test every 4 weeks.

Sponsors & Collaborators

• Research Council of Lithuania

  collaborator OTHER

• Lithuanian University of Health Sciences

  collaborator OTHER

• Maastricht University

  collaborator OTHER

• Vrije Universiteit Brussel

  collaborator OTHER

• KU Leuven

  collaborator OTHER

• Wingate Institute

  collaborator OTHER

• Lithuanian Sports University

  lead OTHER

Principal Investigators

• Nerijus Masiulis, PhD · Lithuanian Sports University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

75 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-10-15

Primary Completion

2023-11-17

Completion

2023-11-17

Countries

• Lithuania

Study Locations