Reshaping the Path of Mild Cognitive Impairment by Refining Exercise Prescription

Summary

Dementia is one of the most pressing health care issues of the 21st century. Evidence suggests that exercise enhances cognitive function in healthy older adults. Most research has focused on aerobic training (AT). Therefore, investigators aim to assess the individual effects of AT and resistance training (RT), as well as the interaction effect of combining the two types of exercise training, on cognitive function in older adults with mild cognitive impairment.

Conditions

• Mild Cognitive Impairment

Interventions

BEHAVIORAL

Aerobic Training

Six months of twice-weekly aerobic training that will gradually progress in intensity. Each training session will be 60 minutes (10 minutes of warm-up, 40 minutes of training, and 10 minutes of cool-down). To meet the public health mandates of COVID-19, when it is necessary, training will occur at home, with the use of wearables to monitor heart rate. Participants will be provided access to instructional videos either by YouTube or DVD. They will be called on a weekly basis to monitor progress and adherence.

BEHAVIORAL

Resistance Training

Six months of twice-weekly resistance training program that will gradually progress in intensity. Each training session will be 60 minutes (10 minutes of warm-up, 40 minutes of training, and 10 minutes of cool-down). To meet the public health mandates of COVID-19, when it is necessary, training will occur at home, with the use of a set of resistance bands of various weights. Participants will be provided access to instructional videos either by YouTube or DVD. They will be called on a weekly basis to monitor progress and adherence.

BEHAVIORAL

Balance and Tone Training

Six months of twice-weekly stretching and relaxation program that includes stretching exercises, range of motion exercises, basic core-strength/kegal exercises, static balance exrecises, functional strength exercises (e.g., sit to stand), and relaxation techniques. Each session will be 60 minutes. To meet the public health mandates of COVID-19, when it is necessary, training will occur at home, with the use of small equipment (e.g., pilate ball). Participants will be provided access to instructional videos either by YouTube or DVD. They will be called on a weekly basis to monitor progress and adherence.

BEHAVIORAL

Balance and Tone Training

Six months of twice-weekly stretching and relaxation program that includes stretching exercises, range of motion exercises, basic core-strength/kegal exercises, static balance exrecises, functional strength exercises (e.g., sit to stand), and relaxation techniques. Each session will be 60 minutes. To meet the public health mandates of COVID-19, when it is necessary, training will occur at home, with the use of small equipment (e.g., pilate ball). Participants will be provided access to instructional videos either by YouTube or DVD. They will be called on a weekly basis to monitor progress and adherence.

Sponsors & Collaborators

• University of British Columbia

  lead OTHER

Principal Investigators

• Teresa Liu-Ambrose, PhD, PT · University of British Columbia

• John Best, PhD · University of British Columbia

• Jennifer Davis, PhD · University of British Columbia

• Lara Boyd, PhD · University of British Columbia

• Liisa Galea, PhD · University of British Columbia

• Charlie Goldsmith, PhD · Simon Fraser University

• Ging-Yuek Robin Hsiung, MD, PhD · University of British Columbia

• Alexander MacKay, PhD · University of British Columbia

• Lindsay Nagamatsu, PhD · Western University

• Claudia Jacova, PhD · Pacific University

• Arthur Kramer, PhD · Northeastern University

• Michelle Voss, PhD · University of Iowa

• Cindy Barha, PhD · University of British Columbia

• Joel Singer, PhD · University of British Columbia

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

FACTORIAL

Eligibility

Min Age

65 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-11-13

Primary Completion

2024-08-22

Completion

2025-08-26

Countries

• Canada

Study Locations