Sarcopenia is an age-related loss of muscle mass and strength that can impair daily function and increase risks such as falls and injuries. It is recognized as a diagnosable disease entity in ICD-10-CM.
Recent studies associate blood biomarkers with brain atrophy and cognitive decline in Alzheimer's disease, while new DNA aptamers, retinal imaging, and speech analysis advance neurodegeneration detection and monitoring.
GLP-1 drugs are still being studied for Alzheimer’s and addiction after semaglutide failed to slow cognitive decline in Alzheimer’s. A 2025 abstract reported semaglutide slowed cognitive impairment in an Alzheimer’s model.
Market analysis reports project substantial growth through 2033 across sarcopenia treatments, oncology injection drugs, and ASO-based therapies. Major pharmaceutical companies including Pfizer, Merck, Roche, Novartis, and Amgen feature prominently across all three therapeutic areas. The reports cover market segmentation, geographic analysis, and competitive landscapes for each sector.
Three GLP-1 weight-loss drugs—semaglutide, tirzepatide and retatrutide—reduced weight and improved metabolic health in mice lacking the MC4R gene, offering potential treatment for rare genetic obesity.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07764172 |
Sarcopenia in Acute Ischemic Stroke |
RECRUITING | |
| NCT07761481 |
CT-Determined Sarcopenia and Mortality in Critically Ill Cancer Patients |
COMPLETED | |
| NCT07761091 |
Effectiveness of Nutrition and Exercise Interventions in Older Adults With Sarcopenia in Can Gio District, Ho Chi Minh City |
COMPLETED | NA |
| NCT07760948 |
HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide |
NOT_YET_RECRUITING | PHASE2 |
| NCT07757984 |
Regional Nerve Block for Upper Extremity Surgery in Patients With Sarcopenia |
NOT_YET_RECRUITING | |
| NCT07751692 |
GNRI and Rectus Femoris Muscle Thickness in Older Patients Undergoing Hip Fracture Surgery |
NOT_YET_RECRUITING | |
| NCT07749118 |
HB05P on Muscle Health |
RECRUITING | NA |
| NCT07747805 |
GLP-1 Agonists for Lung Function Improvement and Muscle Restoration in COPD |
NOT_YET_RECRUITING | PHASE2 |
| NCT07741786 |
PNF Versus Conventional Exercise in Sarcopenia |
COMPLETED | NA |
| NCT07734506 |
RELATIONSHIP BETWEEN ULTRASONOGRAPHIC QUADRICEPS MUSCLE THICKNESS AND SARCOPENIA MARKERS (HANDGRIP STRENGTH, SARC-F) AND KINESIOPHOBIA IN STROKE PATIENTS |
RECRUITING |
