A review of more than 200 studies linked up to a third of dementia cases to diseases outside the brain. Trials and broader evidence also support multi-domain prevention strategies.
Two studies of older adults with type 2 diabetes linked diabetic retinal disease with higher dementia risk. DME and more severe diabetic retinopathy were associated with higher all-cause and vascular dementia risk, but not consistently with Alzheimer’s disease.
A major evidence review of 17 clinical trials involving more than 20,000 participants found anti-amyloid Alzheimer’s drugs had absent or trivial effects on cognitive decline and dementia. The review also said the drugs likely increase the risk of brain swelling and bleeding.
A new Cochrane review said anti-amyloid Alzheimer’s drugs show no clinically meaningful benefit, but many researchers said the analysis has major limitations. Newer evidence on lecanemab and donanemab and broader drug development efforts continue to shape the field.
CervoMed presents new MRI data showing neflamapimod may reduce basal forebrain atrophy in dementia with Lewy bodies and finalizes Phase 3 trial design. The drug has also been selected for a UK-funded ALS platform trial, with first dosing expected by end of 2026.
People with blood type B have a 28% higher risk of type 2 diabetes, while artificial sweetener consumption is linked to faster cognitive decline, particularly in younger adults and those with diabetes. The blood type finding comes from an umbrella review of 51 systematic reviews, while the sweetener study followed 12,772 Brazilian adults for eight years.
Recent studies demonstrate brain stimulation therapies can accelerate depression treatment to five days and low-dose lithium may slow cognitive decline in seniors with mild cognitive impairment.
Recent studies examine biological factors affecting sleep in older adults, finding connections between inflammatory markers, antioxidant capacity, and sleep quality in aging populations.
Recent research shows younger heart disease patients face unique parenting challenges, middle-aged healthy eating protects against cognitive decline, and timing evening meals three hours before bed improves cardiovascular markers.
Researchers at UC San Francisco discovered that exercise triggers liver production of GPLD1, which removes TNAP protein buildup from blood-brain barrier cells, reducing age-related leakiness and cognitive decline.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07600567 |
Algal Lutein Against Decline of Intellectual Nimbleness |
NOT_YET_RECRUITING | NA |
| NCT07564804 |
A Clinical Trial to Investigate the Efficacy of the Brain Blossom Supplement to Improve Cognitive Function and Memory |
COMPLETED | NA |
| NCT07547319 |
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NOT_YET_RECRUITING | NA |
| NCT07491120 |
The CDAC Study - Cerebral Dysfunction After Coronary Revascularization |
NOT_YET_RECRUITING | |
| NCT07443189 |
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COMPLETED | NA |
| NCT07422220 |
Long-Term Effects of Walnut Consumption on Brain Function |
NOT_YET_RECRUITING | NA |
| NCT07399418 |
TRIAD - Tracking Risk in Integrated Alzheimer's Diagnostics. |
RECRUITING | |
| NCT07394504 |
Effects of Turning Based Dual Task Training on Balance and Mild Cognitive Impairment in Diabetic Peripheral Neuropathy |
COMPLETED | NA |
| NCT07387523 |
Psychological and Lifestyle Factors That Predict Adherence of Multi-domain Interventions for Promoting Brain Health |
ENROLLING_BY_INVITATION | NA |
| NCT07334366 |
Broccoli Sprout Extract for Cognitive Function |
RECRUITING | NA |
