Exercise and Brain in Coronary Heart Disease

Summary

The Heart-Brain project is a randomized controlled trial designed to examine the effects of two different exercise programs of 12-week duration: 1) aerobic high intensity interval training (HIIT), and 2) aerobic HIIT plus resistance training, on brain health and other outcomes in coronary heart disease patients.

Conditions

• Coronary Heart Disease

Interventions

BEHAVIORAL

Two types of exercise interventions

* HIIT. 3 times/week. This consists of a 4x4 HIIT (preferably in treadmill), 4 intervals of 4min at high intensity (85-95% HRmax) and 3 intervals of 3min of active resting at \~70% HRmax in between. All sessions including 10 min of warming-up and 10min of cooling down, resulting in 45min sessions. The first 2 weeks will progress from moderate-intensity training to HIIT for a better adaptation and acceptability of the program. * HIIT + resistance. 3 times/week. The aerobic part consists of a 3x4 HIIT (preferably in treadmill), 3 intervals of 4min at high intensity (85-95% HRmax) and 2 intervals of 3min of active resting (\~70% HRmax) in between. The resistance part consists of 2 series of an 8-exercise circuit (combination of upper and lower body exercises using elastic bands and body weight) with a ratio of 20sec of effort - 40sec of resting. Sessions will have 5min of warming up in the treadmill and 5min of cooling down walking in the gym, comprising a total of 45min sessions.

Sponsors & Collaborators

• Instituto Mixto Universitario Deporte y Salud (iMUDS)

  collaborator UNKNOWN

• Centro de Investigación Mente, Cerebro y Comportamiento (CIMCYC)

  collaborator UNKNOWN

• University Hospital Virgen de las Nieves

  collaborator OTHER

• Hospital Clinico Universitario San Cecilio

  collaborator OTHER

• Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN)

  collaborator UNKNOWN

• Universidad de Granada

  lead OTHER

Principal Investigators

• Francisco B Ortega, Professor · Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Spain

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

50 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-04-19

Primary Completion

2024-06-01

Completion

2024-06-01

Countries

• Spain

Study Locations